The toys are mistakenly delivered to a day-care center instead of the attic right before Andy leaves for college, and it’s up to Woody to convince the other toys that they weren’t abandoned and to return home.
Woody, Buzz and the whole gang are back. As their owner Andy prepares to depart for college, his loyal toys find themselves in daycare where untamed tots with their sticky little fingers do not play nice. So, it’s all for one and one for all as they join Barbie’s counterpart Ken, a thespian hedgehog named Mr. Pricklepants and a pink, strawberry-scented teddy bear called Lots-o’-Huggin’ Bear to plan their great escape.
With their beloved Andy preparing to leave for college, Woody, Buzz Lightyear, Jessie, and the rest of the toys find themselves headed for the attic but mistakenly wind up on the curb with the trash. Woody’s quick thinking saves the gang, but all but Woody end up being donated to a day-care center. Unfortunately, the uncontrollable kids do not play nice, so Woody and the gang make plans for a great escape.
As their owner Andy begins preparing for college, Woody, Buzz and their friends feel like they need to move on as well. The toys are then mistakenly sent to a local daycare center with the intention to be played with again. But their enthusiasm is short lived when they discover the true nature of their new home which is run by the dictatorship of an evil bear named Lotso. Now it’s up to Woody to rescue his friends and plan a daring escape in order to returning home before Andy is gone forever.
Andy is going to college and doesn’t play with his toys anymore causing Woody and the others to be donated to Sunnyside Daycare, where they discover that the place is not exactly what they dreamed it was, and will have to face many dangers to come home safely.