When three different animals become infected with a dangerous pathogen, a primatologist and a geneticist team up to stop them from destroying Chicago.
Athena-1, a space station owned by gene manipulation company Energyne, is destroyed after a laboratory rat mutates and wreaks havoc. Dr. Kerry Atkins, the lone surviving crew member, is ordered by CEO Claire Wyden to retrieve research canisters containing a pathogen. Atkins is able to flee in the escape pod when the station implodes, but due to damage from the rat it disintegrates upon re-entry, killing her. The falling pieces leave a trail of debris across the United States, including the Everglades in Florida, where a canister is consumed by an American crocodile, and a forest in Wyoming, where a gray wolf is exposed to the pathogen. Primatologist Davis Okoye, a former US Army Special Forces soldier and member of an anti-poaching unit, works at the San Diego Wildlife Sanctuary. He has befriended a rare albino western lowland gorilla named George, having saved him from poachers, and communicates with George using sign language and hand gestures. At night, one of the canisters crash-lands in George’s habitat, and George is exposed to the pathogen..
Primatologist Davis (Dwayne Johnson) shares an unshakable bond with George, the extraordinarily intelligent silverback gorilla who has been in his care since he was young. When a greed-fueled corporation’s genetic experiment goes awry, George and other animals across the country are mutated into aggressive supercreatures who destroy everything in their path. In this adrenaline-filled ride, Davis tries to find an antidote, not only to halt a global catastrophe but also to save the fearsome creature who was once his friend.
Sharing a special bond with George, the extraordinary albino silver-back gorilla, the retired U.S. Army soldier and now a San Diego Wildlife Preserve primatologist, Davis Okoye, will see everything in his life turn upside down when his intelligent companion is accidentally exposed to Dr Kate Caldwell’s gene-mutating pathogen. As George along with two other unsuspecting animals grow into ravenous monsters of gargantuan proportions, a frenzied race against the clock commences, as Davis and Dr Kate struggle to find a possible antidote. Suddenly, Chicago becomes a dangerous battlefield. Can the team make it in time before the mutants level the entire city?